Novel mitochondrial genome rearrangements including duplications and extensive heteroplasmy could underlie temperature adaptations in Antarctic notothenioid fishes

Abstract Mitochondrial genomes are known for their compact Neck size and conserved gene order, however, recent studies employing long-read sequencing technologies have revealed the presence of atypical mitogenomes in some species.In this study, we assembled and annotated the mitogenomes of five Antarctic notothenioids, including four icefishes (Cha

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Interactions between nitric oxide, gibberellic acid, and phosphorus regulate primary root growth in Arabidopsis

Nitric oxide (NO), gibberellic acid (GA), and phosphorus (P) straw have been reported to regulate primary root (PR) growth, but interactions between them in the growth of Arabidopsis PR remain unknown.This work confirmed that low P availability significantly inhibited PR growth and that NO arrested PR growth in either high P or low P conditions.Mor

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A novel diagnostic model for predicting immune microenvironment subclass based on costimulatory molecules in lung squamous carcinoma

There is still no ideal predictive biomarker for immunotherapy response among patients with non-small cell lung cancer.Costimulatory molecules play a role in anti-tumor immune response.Hence, they can be a potential biomarker for immunotherapy response.The current study comprehensively investigated the expression of costimulatory molecules in lung

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Effect of Purple Corn Anthocyanin on Antioxidant Activity, Volatile Compound and Sensory Property in Milk During Storage and Light Prevention

The aim of this study was to observe the effect of purple corn anthocyanin on the light-induced antioxidant Maintenance Box activity, free radicals, volatile compounds, color parameters, and sensory properties of milk during storage.There were four groups: (1) negative control, no addition of anthocyanins + exposure to fluorescent light (NC); (2) p

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Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4

Although clinical evidence suggests that nonalcoholic fatty liver disease is an established major risk factor for heart failure, it remains unexplored whether sleep disorder-caused hepatic damage contributes to the development of cardiovascular disease (CVD).Here, our findings revealed that sleep fragmentation (SF) displayed notable hepatic detrime

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